Shanghai Haoyuan Chemexpress Co.Ltd(688131) : annual internal control evaluation report

Company code: Shanghai Haoyuan Chemexpress Co.Ltd(688131) company abbreviation: Shanghai Haoyuan Chemexpress Co.Ltd(688131) Shanghai Haoyuan Chemexpress Co.Ltd(688131)

Internal control evaluation report in 2021

Shanghai Haoyuan Chemexpress Co.Ltd(688131) all shareholders:

In accordance with the provisions of the basic norms of enterprise internal control and its supporting guidelines and other internal control regulatory requirements (hereinafter referred to as the enterprise internal control normative system), combined with the company’s (hereinafter referred to as the company’s) internal control system and evaluation methods, and on the basis of daily and special supervision of internal control, we evaluated the effectiveness of the company’s internal control on December 31, 2021 (the benchmark date of internal control evaluation report). I Important statement

It is the responsibility of the board of directors of the company to establish, improve and effectively implement internal control, evaluate its effectiveness and truthfully disclose the internal control evaluation report in accordance with the provisions of the enterprise’s internal control standard system. The board of supervisors shall supervise the establishment and implementation of internal control by the board of directors. The management is responsible for organizing and leading the daily operation of the enterprise’s internal control. The board of directors, the board of supervisors and the directors, supervisors and senior managers of the company guarantee that there are no false records, misleading statements or major omissions in the contents of this report, and bear individual and joint legal liabilities for the authenticity, accuracy and completeness of the contents of the report.

The objective of the company’s internal control is to reasonably ensure the legal compliance of operation and management, asset safety, authenticity and integrity of financial reports and relevant information, improve operation efficiency and effect, and promote the realization of development strategy. Due to the inherent limitations of internal control, it can only provide reasonable assurance for the realization of the above objectives. In addition, as changes in circumstances may lead to inappropriate internal control or reduced compliance with control policies and procedures, there is a certain risk to speculate the effectiveness of internal control in the future according to the internal control evaluation results. II Internal control evaluation conclusion 1 On the benchmark date of the internal control evaluation report, does the company have any major defects in the internal control of financial reporting □ yes √ No 2 Evaluation conclusion of internal control over financial reporting √ valid □ invalid

According to the identification of major defects in the company’s internal control over financial reporting, there are no major defects in the internal control over financial reporting on the benchmark date of the internal control evaluation report. The board of Directors believes that the company has maintained effective internal control over financial reporting in all major aspects in accordance with the requirements of the enterprise’s internal control standard system and relevant regulations. 3. Whether major defects in internal control over non-financial reporting are found □ yes √ no

According to the identification of major defects in the company’s internal control over non-financial reports, the company found no major defects in the company’s internal control over non-financial reports on the benchmark date of the internal control evaluation report. 4. Factors affecting the evaluation conclusion of internal control effectiveness from the base date of internal control evaluation report to the date of issuance of internal control evaluation report

There are no factors affecting the evaluation conclusion of the effectiveness of internal control from the base date of the internal control evaluation report to the date of issuance of the internal control evaluation report. 5. Whether the internal control audit opinion is consistent with the company’s evaluation conclusion on the effectiveness of internal control over financial reporting √ yes □ No 6 Whether the disclosure of major defects in internal control of non-financial reports in the internal control audit report is consistent with the disclosure of the company’s internal control evaluation report √ yes □ no III Internal control evaluation (I) Scope of internal control evaluation

According to the risk oriented principle, the company determines the main units, businesses and matters included in the evaluation scope and high-risk areas. 1. The main units included in the evaluation scope include: Shanghai Haoyuan Chemexpress Co.Ltd(688131) , Shanghai Haoyuan Biomedical Technology Co., Ltd., Shanghai Haohong Biomedical Technology Co., Ltd., Shanghai Kaixin Biomedical Technology Co., Ltd., Haoyuan Technology Development Co., Ltd., Anhui Haoyuan Pharmaceutical Co., Ltd., medchemexpress LLC, chemscene limited license company, Anhui Leyan Biomedical Technology Co., Ltd Shanghai Haoyuan Biochemical Technology Co., Ltd., Yantai Haoyuan Biomedical Technology Co., Ltd., Nanjing jinglide Technology Co., Ltd., Hefei ouchuang gene Biotechnology Co., Ltd. and Hefei Renchuang gene Biotechnology Co., Ltd. 2. Proportion of units included in the scope of evaluation:

Proportion of indicators (%)

The total assets of the units included in the evaluation scope account for 100% of the total assets in the company’s consolidated financial statements

The total operating income of the units included in the evaluation scope accounts for 100% of the total operating income in the company’s consolidated financial statements

3. The main operations and matters included in the scope of evaluation include:

Governance structure, organizational structure, capital activities, sales and collection, procurement and payment, cost accounting and expense, inventory and other asset management, major investment, related party transactions, external guarantee, information system and internal communication, information disclosure, raised fund management, etc. 4. High risk areas of focus mainly include:

Sales and collection, major investment and information disclosure. 5. The above units, businesses and matters included in the evaluation scope and high-risk areas cover the main aspects of the company’s operation and management. Is there any major omission □ yes √ No 6 Whether there is legal exemption □ yes √ No 7 Other explanatory matters

(2) Basis of internal control evaluation and identification standard of internal control defects

The company organizes and carries out internal control evaluation according to the enterprise internal control standard system and the company’s internal control system. 1. Whether the specific identification standard of internal control defects is adjusted from previous years □ yes √ no

The board of directors of the company distinguished the internal control of financial report from the internal control of non-financial report according to the identification requirements for major defects, important defects and general defects of the enterprise internal control standard system, combined with the factors such as the company’s size, industry characteristics, risk preference and risk tolerance, and studied and determined the specific identification standards of internal control defects applicable to the company, which are consistent with the previous years. 2. Identification standard of internal control defects in financial reporting

The quantitative criteria for the evaluation of internal control defects in financial reporting determined by the company are as follows:

Index name major defect quantitative standard important defect quantitative standard general defect quantitative standard

Impact of misstatement on pre tax profit of this year (5%, ∞) (2%, 5%) (0%, 2%)

Description: None

The qualitative criteria for the evaluation of internal control defects in financial reporting determined by the company are as follows:

Qualitative standard of defect nature

Major defects 1. Ineffective control environment at the company level;

2. There are significant misstatements in the current financial report, but the internal control fails to find misstatements in the operation process;

3. The supervision of internal audit institutions on internal control is invalid;

4. Major errors in the financial report have not been corrected;

5. Any degree of fraud involving senior management.

Important defects 1. There are general misstatements in the current financial report, but the internal control fails to find misstatements in the operation process;

2. Failure to select and apply accounting policies in accordance with GAAP;

3. No anti fraud procedures and control measures have been established.

General defects and other internal control defects that do not constitute major defects or important defects.

Note: none 3 Identification standard of internal control defects in non-financial reporting

The quantitative criteria for the evaluation of internal control defects in non-financial reporting determined by the company are as follows:

Index name major defect quantitative standard important defect quantitative standard general defect quantitative standard

nothing

Description: None

The qualitative criteria for the evaluation of internal control defects in non-financial reporting determined by the company are as follows:

Qualitative standard of defect nature

Major defects 1. Violation of national laws and regulations and punishment

2. Vicious negative news frequently appears in the media, involving a wide range, and the negative impact has not been eliminated

3. Serious loss of managers and technicians in key positions

4. Causing major safety accident

5. Major mistakes in decision-making procedures

Important defects 1. There are defects in important business systems or systems

2. Violation of internal rules and regulations of the enterprise, resulting in losses

3. The decision-making process led to general errors

General defects and other internal control defects that do not constitute major defects or important defects

Note: none (III) Identification and rectification of internal control defects 1 Identification and rectification of internal control defects in financial reporting 1.1 Major defects

Whether the company has major defects in internal control over financial reporting during the reporting period □ yes √ no 1.2 Important defects

Whether the company has significant defects in internal control over financial reporting during the reporting period □ yes √ no 1.3 General defect

None 1.4 After the above rectification, on the benchmark date of the internal control evaluation report, does the company have any major defects in the internal control of financial reporting that have not been rectified □ yes √ no 1.5 After the above rectification, on the benchmark date of the internal control evaluation report, whether the company has any important defects in the internal control of financial reporting that have not been rectified □ yes √ No 2 Identification and rectification of internal control defects in non-financial reporting 2.1 Major defects

Whether the company found any major defects in internal control over non-financial reporting during the reporting period □ yes √ no 2.2 Important defects

Whether the company found any significant defects in internal control over non-financial reporting during the reporting period □ yes √ no 2.3 General defect

nothing

2.4. After the above rectification, on the benchmark date of the internal control evaluation report, does the company find any major defects in the non-financial reporting internal control that have not been rectified □ yes √ no 2.5 After the above rectification, on the benchmark date of the internal control evaluation report, whether the company finds any important defects in non-financial reporting internal control that have not been rectified □ yes √ no IV Description of other major matters related to internal control 1 Rectification of internal control defects in the previous year □ applicable √ not applicable 2 Operation of internal control in this year and improvement direction in the next year □ applicable √ not applicable 3 Description of other major events □ applicable √ not applicable

Chairman (authorized by the board of directors): Zheng Baofu Shanghai Haoyuan Chemexpress Co.Ltd(688131)

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