Listing recommendation letter of Zhongtian Guofu Securities Co., Ltd. on Shenzhen Dake's initial public offering of shares and listing on the gem (draft report)

Zhongtian Guofu Securities Co., Ltd

about

Shenzhen dakowei Biotechnology Co., Ltd

Initial public offering and listing on GEM

of

Listing recommendation

Sponsor (lead underwriter)

(centralized business (North) of financial business district, zone B, Zhongtian Convention and Exhibition City, Changling North Road, guanshanhu District, Guiyang City, Guizhou Province)

Zhongtian Guofu Securities Co., Ltd

About Shenzhen dakowei Biotechnology Co., Ltd

Listing recommendation letter for initial public offering and listing on GEM

Zhongtian Guofu Securities Co., Ltd. (hereinafter referred to as "Zhongtian Guofu securities" and "sponsor") is entrusted by Shenzhen dakoway Biotechnology Co., Ltd. (hereinafter referred to as "dakoway", "issuer" or "company") as the sponsor of its initial public offering of shares and listing on the gem (hereinafter referred to as "this securities offering" or "this offering"), Issue a listing recommendation letter for this offering.

In accordance with the company law of the people's Republic of China (hereinafter referred to as the "company law"), the securities law of the people's Republic of China (hereinafter referred to as the "Securities Law"), the measures for the administration of securities issuance and listing recommendation business (hereinafter referred to as the "measures for the administration of recommendation") and the measures for the administration of the registration of initial public offerings of gem (for Trial Implementation) (hereinafter referred to as the "measures for the registration of gem") The Shenzhen Stock Exchange GEM Listing Rules (revised in December 2020) (hereinafter referred to as the "GEM Listing Rules") and other relevant laws and regulations, as well as the relevant provisions of the CSRC and Shenzhen Stock Exchange. The recommendation institutions and recommendation representatives issue the listing recommendation letter in strict accordance with the business rules and industry self-discipline norms formulated according to law in the spirit of honesty, trustworthiness, diligence and responsibility, And ensure that the documents issued are true, accurate and complete.

Unless otherwise specified in the text, the meaning of the abbreviation used in this listing recommendation is consistent with the prospectus of Shenzhen Dake Biotechnology Co., Ltd. for initial public offering and listing on the gem.

catalogue

catalogue 2 I. Basic information of the issuer three

(I) overview of the issuer three

(II) main business three

(III) core technology and R & D level six

(IV) main business and financial data and indicators nineteen

(V) main risks 20 II. Basic information of this securities issuance 24 III. information about the sponsor representative, project coordinator and other members of this securities issuance and listing twenty-five

(I) sponsor representative: twenty-five

(II) Project Co sponsor twenty-six

(III) other members of the project team 26 IV. there is no explanation that the recommendation institution may affect the fair performance of its recommendation duties 26 v. commitments of the sponsor Vi. decision making procedures performed by the Issuer on this securities issuance and listing 29 VII. Verification of the sponsor's compliance with the positioning of the gem VIII. Verification by the recommendation institution that the issuer complies with the GEM Listing Rules thirty-five

(I) the issuer complies with Article 2.1.1 of the GEM Listing Rules thirty-five

(II) the issuer complies with Article 2.1.2 of the GEM Listing Rules 38 IX. specific arrangements for the sponsor's continuous supervision after the issuer's securities are listed X. recommendation conclusion of the recommendation institution on the issuance and listing of Securities thirty-nine

1、 Basic information of the issuer

(I) overview of the issuer

Shenzhen dakowei Biotechnology Co., Ltd

English Name: Dakewe biotech Co., Ltd

The registered capital is 59.967 million yuan

Legal representative: Wu Qingjun

Unified social credit code 91440 Jiangsu Canlon Building Materials Co.Ltd(300715) 244316l

Date of establishment of the company: November 4, 1999

Date of incorporation: March 22, 2016

Address: 1501 and 1502, building D3, Nanshan Zhiyuan, No. 1001, Xueyuan Avenue, Changyuan community, Taoyuan Street, Nanshan District, Shenzhen

Postal Code: 518073

Tel: 075526413840

Fax: 075526413840

Internet address http://www.dakewe.com.

E-mail [email protected].

General business items are: import and export business, China Trade (excluding franchised, specially controlled and franchised commodities); Biotechnology consulting, R & D and sales of scientific instruments and reagents (excluding flammable, explosive, hazardous chemicals and other restricted items). Permitted business scope: Class II and class III 6858 medical cold therapy, low temperature and refrigeration equipment and appliances, class II 6841 medical laboratory and basic equipment and appliances, class II and class III 6840 clinical inspection and analysis instruments, class II 6826 physical therapy and rehabilitation equipment, class II Class III 6821 medical electronic instruments and equipment (except class III 6821-1, 6821-2 and 6821-3).

(II) main business

The company is a professional provider focusing on life science research services and pathological diagnosis. In the field of life science research services, the company is mainly engaged in the agent sales of scientific research reagents and instruments, as well as the independent R & D, production and sales of some scientific research reagents; In the field of pathological diagnosis, the company is mainly engaged in the R & D, production and sales of pathological diagnosis equipment and reagents.

The company is committed to introducing the international Frontier Biotechnologies Inc(688221) technology brand into China, providing comprehensive products and technical support services for scientific research customers, paying attention to independent innovation in the field of clinical application, and establishing a certain competitive advantage in the field of life science research services and pathological diagnosis. The company has 115 patents, including 21 invention patents. In terms of reagent products, the company has mastered the core technologies such as cytokine quantitative detection technology and cell separation and culture technology. Dake, a wholly-owned subsidiary of the company, is a bioengineering enterprise and was selected as a "specialized and special new" small giant enterprise by the Ministry of industry and information technology in 2021; In terms of pathological diagnosis equipment, the company has mastered the key technologies of core products such as dyeing machine, sealing machine, frozen slicer and dehydrator. The company's automatic dyeing and sealing machine, automatic dehydrator and other products have been selected into the catalogue of excellent domestic medical equipment products. With long-term industry deep cultivation, continuous technical exploration, profound R & D strength and comprehensive and rapid service ability, the company has established a good brand image in the industry and accumulated high-quality, extensive and stable customer groups. During the reporting period, the company has served more than 9000 customers, including strategic emerging biotechnology enterprises represented by legendary biology, Wuxi Apptec Co.Ltd(603259) , Cinda biology, etc; Key grade III hospitals represented by Peking Union Medical College Hospital of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University and General Hospital of Chinese people's Liberation Army; Colleges and universities represented by Peking University, Tsinghua University and Zhejiang University; The Chinese Academy of Military Sciences and the Chinese Academy of medical sciences as representatives; Third party testing institutions represented by Guangzhou Kingmed Diagnostics Group Co.Ltd(603882) , Lanwei inspection and Huayin health.

1. Life science research reagents and instruments

In the field of life science research services, according to the experimental and testing needs related to scientific research of customers such as biomedical enterprises, colleges and universities, scientific research institutes and medical institutions, the company mainly provides scientific research reagents, scientific research instruments and consumables, and provides strong product and technical support for the majority of scientific researchers to create first-class scientific research achievements. After more than 20 years of development, the company has continuously deepened the R & D and sales of its own products based on agency business in the field of life science research and services, and formed a business model based on third-party brands and the rapid development of its own products.

Due to the large number of sub fields and directions of life science research, wide range, and different requirements for reagents in different application scenarios, the characteristics of scientific research reagent products are strong professionalism, wide variety and quantity of products, scattered application fields, limited variety of single brand products, large and scattered customer groups, diversified customer needs, high frequency of customer procurement and small batch. In order to respond in time and meet the extensive needs of different customers for scientific research reagents, the company mainly integrates more than 100 international biotechnology brands such as biolegend, peprotech, invivogen, LGC and elitecell in the form of sole agent and primary agent to provide scientific research reagent products and related services for basic scientific research directions such as immunology, cell biology and molecular biology, And gradually formed a comprehensive and professional scientific research reagent comprehensive service ability. After more than 20 years of development, the company has rapidly developed its own brand scientific research reagent products through continuous in-depth research and development on the basis of agency business. The company has established reagent brands "Dayou" and "biosci", covering scientific research fields such as cell biology and molecular biology, and forms professional customer service solutions together with agent products.

2. Pathological diagnosis equipment and reagents

In the field of pathological diagnosis, the company mainly provides customers such as hospital pathological departments and third-party testing institutions with independently developed and produced pathological diagnosis equipment, pathological diagnosis reagents and other products.

With years of industry deep cultivation and technology accumulation in the field of life science research and service, the company can accurately grasp the development trend of pathological diagnosis industry and technology. After comprehensive consideration of the development prospect of the industry and its own technical foundation, the company chose the field of pathological diagnosis for business development, and mastered the key technologies of core products such as dyeing machine, sealing machine, frozen slicer and dehydrator through independent research and development, And formed its own equipment brand "dakowi".

Since 2013, the company has independently developed pathological diagnosis equipment products. The company's pathological diagnosis equipment has expanded from a single product to a multi product line, gradually covering the main experimental processes of histopathology. The company's pathological diagnosis equipment products include dyeing machine, sealing machine, frozen slicer, dehydrator, etc., covering the key processes of tissue dehydration, slicing, dyeing and so on in pathological diagnosis. On the basis of pathological diagnosis equipment, the company also provides customers with pathological diagnosis reagents and consumables. As one of the early enterprises engaged in the research, development and production of pathological diagnosis products in China, with the leading technical level, the company's pathological diagnosis products have strong market competitiveness. It is one of the few Chinese manufacturers to realize the large-scale sales of histopathological diagnosis equipment in class III hospitals, and one of the few Chinese manufacturers that can compete with the international first-line brands of pathological diagnosis equipment such as Leica, cherry blossom and semefier. At the same time, the company's pathological diagnosis equipment has been sold in the United States, Canada, Germany, France, Italy and other countries and regions.

3. Other business

In addition to the related businesses in the field of life science research services and pathological diagnosis, the company provides a series of blood collection equipment such as integrated blood collection platform, blood collection scale, tube sealing heat sealer, plasma melting instrument, blood collection chair and so on for customers such as blood collection and supply institutions through agency and independent research, development and production.

In 2020, facing the impact of covid-19 epidemic, the company independently developed virus preservation reagent products for nucleic acid detection sample collection and storage by virtue of its profound technical accumulation in the field of scientific research reagents. The virus preservation reagent products of the company have obtained the product certification or registration of many countries and regions, such as FDA license of the U.S. Food and drug administration, CE certification of the European Union, cibg certification of the Netherlands and so on.

(III) core technology and R & D level

The company's core technology is mainly reflected in the product technology with its own brand as the core and the comprehensive service ability with scientific research service as the core.

Product technology: after more than 20 years of development and continuous in-depth research and development, the company has gradually formed its own brand life science research reagents and pathological diagnosis equipment. The company's own brand life science research reagents and pathological diagnosis equipment are the direct embodiment of the company's product technology.

Comprehensive service capability: the comprehensive service capability of the company is mainly reflected in the technical support services provided by the company in the sales process of agent scientific research reagent products. With many years of industry experience and professional talent team in the field of agent scientific research reagents, the company provides downstream customers with corresponding technical services such as product screening and recommendation, relevant experimental design and technical guidance in the pre-sales and after-sales links of sales agent reagents, which improves the user experience of downstream customers and enhances the customer stickiness of the company.

As of the end of the reporting period, the main core technologies owned by the company are as follows:

1. Main core technologies of reagent products

Serial number core technology core technology name technology corresponding product technology maturity category source

Enzyme linked immunosorbent assay independent ELISAkit technology is mature, technology research and development to achieve mass production

1 cytokine determination enzyme-linked immunospot technology independent ELISPOT kit technology maturity and quantitative detection technology research and development

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