Star Lake Bioscience Co.Inc.Zhaoqing Guangdong(600866) : Star Lake Bioscience Co.Inc.Zhaoqing Guangdong(600866) internal control evaluation report

Star Lake Bioscience Co.Inc.Zhaoqing Guangdong(600866)

Internal control evaluation report in 2021

Star Lake Bioscience Co.Inc.Zhaoqing Guangdong(600866) all shareholders:

In accordance with the provisions of the basic norms of enterprise internal control and its supporting guidelines and other internal control regulatory requirements (hereinafter referred to as the enterprise internal control normative system), combined with the company’s (hereinafter referred to as the company’s) internal control system and evaluation methods, and on the basis of daily and special supervision of internal control, we evaluated the effectiveness of the company’s internal control on December 31, 2021 (the benchmark date of internal control evaluation report). I Important statement

It is the responsibility of the board of directors of the company to establish, improve and effectively implement internal control, evaluate its effectiveness and truthfully disclose the internal control evaluation report in accordance with the provisions of the enterprise’s internal control standard system. The board of supervisors shall supervise the establishment and implementation of internal control by the board of directors. The management is responsible for organizing and leading the daily operation of the enterprise’s internal control. The board of directors, the board of supervisors and the directors, supervisors and senior managers of the company guarantee that there are no false records, misleading statements or major omissions in the contents of this report, and bear individual and joint legal liabilities for the authenticity, accuracy and completeness of the contents of the report.

The objective of the company’s internal control is to reasonably ensure the legal compliance of operation and management, asset safety, authenticity and integrity of financial reports and relevant information, improve operation efficiency and effect, and promote the realization of development strategy. Due to the inherent limitations of internal control, it can only provide reasonable assurance for the realization of the above objectives. In addition, as changes in circumstances may lead to inappropriate internal control or reduced compliance with control policies and procedures, there is a certain risk to speculate the effectiveness of internal control in the future according to the internal control evaluation results. II Internal control evaluation conclusion 1 On the benchmark date of the internal control evaluation report, does the company have any major defects in the internal control of financial reporting

□ yes √ no

2. Evaluation conclusion of internal control over financial reporting

√ valid □ invalid

According to the identification of major defects in the company’s internal control over financial reporting, there are no major defects in the internal control over financial reporting on the benchmark date of the internal control evaluation report. The board of Directors believes that the company has maintained effective internal control over financial reporting in all major aspects in accordance with the requirements of the enterprise’s internal control standard system and relevant regulations.

3. Whether major defects in internal control over non-financial reporting are found

□ yes √ no

According to the identification of major defects in the company’s internal control over non-financial reports, the company found no major defects in the company’s internal control over non-financial reports on the benchmark date of the internal control evaluation report. 4. Factors affecting the evaluation conclusion of internal control effectiveness from the benchmark date of internal control evaluation report to the date of issuance of internal control evaluation report □ applicable √ not applicable

There are no factors affecting the evaluation conclusion of the effectiveness of internal control from the base date of the internal control evaluation report to the date of issuance of the internal control evaluation report. 5. Whether the internal control audit opinion is consistent with the company’s evaluation conclusion on the effectiveness of internal control over financial reporting

√ yes □ No 6 Whether the disclosure of major defects in internal control of non-financial reports in the internal control audit report is consistent with the disclosure of the company’s internal control evaluation report √ yes □ no III Internal control evaluation (I) Scope of internal control evaluation

According to the risk oriented principle, the company determines the main units, businesses and matters included in the evaluation scope and high-risk areas. 1. The main units included in the evaluation scope include the company headquarters, Xinghu bioengineering base, Xinghu biochemical pharmaceutical factory, Dinghu sales branch, Zhaodong Xinghu Biotechnology Co., Ltd. and Sichuan Jiuling Pharmaceutical Technology Co., Ltd. 2. Proportion of units included in the scope of evaluation:

Proportion of indicators (%)

The ratio of the total assets of the units included in the evaluation scope to the total assets of the company’s consolidated financial statements is 100.00

The total operating income of the units included in the evaluation scope accounts for 100.00% of the total operating income in the company’s consolidated financial statements

3. The main operations and matters included in the scope of evaluation include:

Organizational structure, development strategy, human resources, social responsibility, corporate culture, capital activities, procurement business, asset management, sales business, research and development, engineering projects, guarantee business, financial reporting, comprehensive budget, contract management, internal information transmission and information system. 4. High risk areas of focus mainly include:

Competitor risk, human resource risk, R & D management risk, engineering management risk, financial reporting risk and market activity risk, etc. 5. The above units, businesses and matters included in the evaluation scope and high-risk areas cover the main aspects of the company’s operation and management. Is there any major omission □ yes √ No 6 Is there a statutory exemption

□ yes √ No 7 Other explanatory matters

None. (2) Basis of internal control evaluation and identification standard of internal control defects

The company organizes and carries out internal control evaluation according to the enterprise internal control standard system, the company’s internal control system, internal control manual and relevant provisions of the company’s management systems. 1. Whether the specific identification standard of internal control defects is adjusted with that of previous years

□ yes √ no

The board of directors of the company distinguished the internal control of financial report from the internal control of non-financial report according to the identification requirements for major defects, important defects and general defects of the enterprise internal control standard system, combined with the factors such as the company’s size, industry characteristics, risk preference and risk tolerance, and studied and determined the specific identification standards of internal control defects applicable to the company, which are consistent with the previous years. 2. Identification criteria for defects in internal control over financial reporting

The quantitative criteria for the evaluation of internal control defects in financial reporting determined by the company are as follows:

Index name major defect quantitative standard important defect quantitative standard general defect quantitative standard

Gross misstatement and misstatement index 2 ≥ 5 ‰ important defects: 1 ‰ ≤ misstatement index 2 < misstatement index 1 ≥ 1 ‰, and misstatement index 2 < 5 ‰ 1 ‰

Notes: 1. Record the sample of misstatement 2. Determine the potential misstatement rate: calculate the amount of potential misstatement (= the cumulative amount in the same direction of the corresponding account) according to the number of misstatement samples and the total number of samples taken × Potential misstatement rate) 4. Calculate the misstatement index

Misstatement indicator 1 = total amount of potential misstatement / current main business income of the inspected unit or total assets at the end of the period, whichever is higher;

Misstatement indicator 2 = total amount of potential misstatement / current main business income of the joint stock company.

5. Misstatement index and defect level

General defects: false report index 1 ≥ 1 ‰, and false report index 2 < 1 ‰

Major defects: 1 ‰≤ false report index 2 < 5 ‰ major defects: false report index 2 ≥ 5 ‰

For the defects affecting the internal control of financial reporting, it is necessary to calculate whether the impact of potential misstatement on the company’s total assets or total operating revenue exceeds the set ratio.

The qualitative criteria for the evaluation of internal control defects in financial reporting determined by the company are as follows:

Qualitative standard of defect nature

Major defects: defects with the following characteristics are major defects:

1) Any degree of fraud found by the company’s management;

2) Major internal control deficiencies that have been found and reported to the management have not been corrected after a reasonable time; 3) Invalid control environment;

4) Defects affecting income trend;

5) The total amount of connected transactions approved by the general meeting of shareholders exceeds the amount of connected transactions;

6) The major misstatement found in the external audit was not first discovered by the company;

7) Other defects that may affect the correct judgment of report users.

Important defects are those with the following characteristics:

1) Failure to select and apply accounting policies in accordance with GAAP;

2) Failure to establish anti fraud procedures and control measures;

3) No corresponding control mechanism has been established or implemented for the accounting treatment of unconventional or special transactions, and there is no corresponding compensatory control;

4) There are one or more defects in the control of the financial reporting process at the end of the period, and it can not reasonably ensure that the prepared financial statements achieve the goal of authenticity and accuracy.

General defects are other defects except major defects and important defects.

Description: none. 3. Identification standard of internal control defects in non-financial reporting

The quantitative criteria for the evaluation of internal control defects in non-financial reporting determined by the company are as follows:

Index name major defect quantitative standard important defect quantitative standard general defect quantitative standard

Direct property loss of 10 million yuan and above, 5 million yuan (inclusive) ~ 10 million yuan, 100000 yuan (inclusive) ~ 5 million yuan (RMB) Description:

According to the quantitative standard, the company determines the level of internal control defects in non-financial reporting according to the amount of direct property losses caused by defects. The qualitative criteria for the evaluation of internal control defects in non-financial reporting determined by the company are as follows:

Qualitative standard of defect nature

Major defects have been officially disclosed to the public and have a negative impact on the disclosure of the company’s periodic reports.

Important defects were punished by national government departments, but did not have a negative impact on the disclosure of the company’s periodic reports.

General defects were punished by government departments below the provincial level (including the provincial level), but did not have a negative impact on the disclosure of the company’s periodic reports.

explain:

According to the qualitative criteria, whether there is a significant negative impact on the company, and determine the level of internal control defects in non-financial reporting. (3) Identification and rectification of internal control defects 1 Identification and rectification of internal control defects in financial reporting 1.1 Major defects

Whether the company has major defects in internal control over financial reporting during the reporting period □ yes √ no 1.2 Important defects

Whether the company has significant defects in internal control over financial reporting during the reporting period □ yes √ no 1.3 General defect

None. 1.4. After the above rectification, on the benchmark date of the internal control evaluation report, does the company have any major defects in the internal control of financial reporting that have not been rectified □ yes √ no 1.5 After the above rectification, on the benchmark date of the internal control evaluation report, whether the company has any important defects in the internal control of financial reporting that have not been rectified □ yes √ No 2 Identification and rectification of internal control defects in non-financial reporting 2.1 Major defects

Whether the company found any major defects in internal control over non-financial reporting during the reporting period □ yes √ no 2.2 Important defects

Whether the company found any significant defects in internal control over non-financial reporting during the reporting period □ yes √ no 2.3 General defect

None. 2.4. After the above rectification, on the benchmark date of the internal control evaluation report, does the company find any major defects in the non-financial reporting internal control that have not been rectified □ yes √ no 2.5 After the above rectification, on the benchmark date of the internal control evaluation report, does the company find any important defects in non-financial reporting internal control that have not been rectified □ yes √ no

IV Description of other major matters related to internal control 1 Rectification of internal control defects in the previous year □ applicable √ not applicable 2 Operation of internal control in this year and improvement direction in the next year

□ applicable √ not applicable 3 Description of other major events

□ applicable √ not applicable

Chairman (authorized by the board of directors): Chen Wu Star Lake Bioscience Co.Inc.Zhaoqing Guangdong(600866) March 25, 2022

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