Since 13 May, 92 confirmed cases and 28 suspected cases of monkeypox have been reported in 12 countries not endemic to monkeypox virus in three who regional offices.
Monkeypox cases often occur in West and Central Africa. This time, they mainly occur in non endemic countries, and the relevant cases have no travel history in monkeypox endemic areas, which is somewhat unusual.
To this end, who calls for raising awareness of monkeypox prevention, which is essential to identify and prevent further outbreaks. Although there are no relevant monkeypox cases in China, some researchers believe that infectious diseases have no borders, and the risk of monkeypox virus import will continue. While paying close attention to the international monkeypox epidemic, we should make preparations in advance.
In recent days, some in vitro diagnostic enterprises in China have successively announced that they are developing monkeypox virus nucleic acid detection kits, and the relevant anti epidemic stocks in the capital market have attracted attention.
On May 23, the share price of several nucleic acid detection stocks in A-Shares rose sharply. For example, the share price of Sansure Biotech Inc(688289) ( Sansure Biotech Inc(688289) . SH) rose 15.84%, and the share price of Shanghai Zj Bio-Tech Co.Ltd(688317) ( Shanghai Zj Bio-Tech Co.Ltd(688317) . SH) also rose 20%. In addition, the stock prices of Guangdong Hybribio Biotech Co.Ltd(300639) ( Guangdong Hybribio Biotech Co.Ltd(300639) . SZ) and Daan Gene Co.Ltd(002030) ( Daan Gene Co.Ltd(002030) . SZ) also increased by more than 6%.
these reagent enterprises are developing
A third-party testing laboratory told the first financial reporter that at present, if we want to detect monkeypox virus, we need monkeypox kit and P2 + laboratory conditions. "Our own laboratory conditions are up to standard, but there is still a lack of commercially available kits."
At present, Sansure Biotech Inc(688289) relevant person in charge told the first financial reporter that relying on the company's covid-19 and the diagnostic technology platform and experience of various sudden emerging infectious pathogens, the company has reserved monkeypox virus nucleic acid detection kit (PCR fluorescent probe method) in its scientific research products. By specifically detecting the nucleic acid fragment of monkeypox virus, monkeypox virus can be quickly identified. The reagent has the characteristics of high sensitivity and simple operation, It is applicable to the rapid diagnosis of related diseases caused by monkeypox virus infection, and is compatible with fluorescent PCR platform and Sansure Biotech Inc(688289) poct platform. It can be quickly applied to the established covid-19 nucleic acid detection platform.
\u3000\u3000 "The company's monkeypox reagent can be detected in 8 minutes on POCT instrument, and 96 samples can be detected in 30 minutes on conventional PCR instrument. The company is actively promoting the overseas registration of the product. In addition, the company's covid-19 related products have served more than 160 countries and regions around the world, helping tens of thousands of laboratories outside China to increase the nucleic acid detection capacity from scratch or several times to tens of times. Based on these covid-19 nucleic acid detection capabilities It can help laboratories in various countries to efficiently carry out the nucleic acid detection of monkeypox virus and help the rapid diagnosis, prevention and control of monkeypox. " Sansure Biotech Inc(688289) relevant person in charge said.
At present, Shanghai Zj Bio-Tech Co.Ltd(688317) on its official official account said that the company's existing CE registered product monkeypox virus nucleic acid determination kit (fluorescent PCR method) can accurately identify monkeypox virus and assist in the accurate diagnosis, prevention and control of related diseases by determining the gene fragments of monkeypox virus through specific fluorescent method. The reagent is easy to operate and can be matched with Shanghai Zj Bio-Tech Co.Ltd(688317) austramic automatic nucleic acid detection platform to automatically complete the rapid and automatic diagnosis of monkeypox virus.
At the same time, Guangdong Hybribio Biotech Co.Ltd(300639) said on the investor interaction platform that the company has the laboratory detection ability of monkeypox virus and has formed laboratory products that can be used for scientific research. The company will continue to pay attention to the dynamics of this matter. In addition, Daan Gene Co.Ltd(002030) said that the company has reserves of monkeypox virus related scientific research products, but there is no relevant certified reagent at present.
In addition to the development of diagnostic methods, whether the relevant vaccines should be stored at present has also attracted much attention.
Monkeypox is a disease caused by monkeypox virus, which can be shared by humans and animals. This virus is closely related to smallpox virus and belongs to the same virus family. The vaccine against smallpox virus also has protective effect on monkeypox virus. The effect of smallpox vaccine on preventing "monkeypox" is about 85%. Since China stopped vaccinating against smallpox (cowpox) in the early 1980s, people under the age of 40 are generally not immune to smallpox and monkeypox.
Sinopharm Group China Bio said through the official official account that the current treatment of monkeypox has not been safely verified, but to control the outbreak of monkeypox, smallpox vaccine, antiviral drugs and vaccinia immunoglobulin can be used. Smallpox was eliminated by mankind in 1977, and China eliminated smallpox 16 years earlier than the world. Smallpox virus has been eliminated, but cowpox still exists.
"Sinopharm China Bio, as the national team of Chinese biomedicine, has sealed up the 'cowpox' after the elimination of smallpox for emergency needs. If there is a war, call back and win." Sinopharm China biology said.
However, most vaccine companies are still on the sidelines.
Kexing biology told the first financial reporter that at present, the company does not reserve relevant smallpox vaccine, it is too early to discuss the development of monkeypox virus vaccine, and there is no relevant monkeypox virus strain in China.
Zhang Lunan, executive director and vice chairman of the board of directors of AI diweixin biology, told China Business News: "the company is evaluating whether to start the development of monkeypox vaccine, and there is no formal decision at the moment. Considering that monkeypox virus is similar to smallpox virus, China has a lot of foundation in this regard, especially the units developing the technical route of live attenuated vaccine."
close monitor virus variation
With the surge of human cases of monkeypox infection in many countries around the world, the who said that recent cases suggest that monkeypox virus has spread among people, which is also a rare phenomenon in monkeypox epidemic.
"Monkeypox virus is a DNA virus. The DNA virus is very stable. It uses a fixed cellular mechanism to replicate the genome. In theory, it rarely mutates." A poxvirus researcher at Pasteur Institute in France told the first financial reporter.
The researchers said that for the latest monkeypox epidemic, there is still only a sketch of the virus genome, so it is difficult to determine the mutations found in gene testing.
Nevertheless, if the DNA virus spreads over a long period of time, the possibility of mutation also exists. To this end, experts called for close monitoring of the variation of monkeypox virus and clarifying the transmission chain of the epidemic as soon as possible.
"If you want to stop the spread of the virus among people, you must understand its transmission chain, such as how people are infected. The transmission chain is very important for the research of infectious diseases.
”The above experts told the first financial reporter.
He also said that by sequencing the virus genes of different cases, we can determine whether they are related, so as to further understand the transmission route of the disease and help judge the transmission of the virus.
"In the past, we thought that the virus was mainly transmitted from animals to people, and the transmission between people almost never happened." He told the first financial reporter that if the stronger communication between people is confirmed this time, strong preventive measures must be taken.
Although researchers believe that monkeypox virus is a weak virus with limited transmission and pathogenicity, they are still worried about whether the new global outbreak of cases is related to the increased infectivity caused by virus mutation.
In addition, who said that there is no clear travel history of monkeypox epidemic areas in the relevant cases found at present, and they are mainly but not limited to men who have sex with men. Will sexual transmission become a new route of transmission?
"Monkeypox virus used to be very rare, so the mode of transmission of the virus has not been fully revealed in the past." A virus expert from a university in Tianjin told the first financial reporter that it is not difficult to control the virus as long as scientific methods are used for prevention and control.
Wangxinyu, deputy chief physician of the infection department of Huashan Hospital Affiliated to Fudan University, recently wrote in the "Huashan infection" official account on monkeypox virus: "It is generally believed that the transmission efficiency of monkeypox virus from person to person is relatively low. Given the abnormally high frequency of transmission between people observed in this epidemic and the possibility of community transmission without a history of going to the epidemic area, epidemiologists believe that there is a high possibility of further transmission of the virus through close contact."
He further said that if monkeypox virus is transmitted between people, it can be transmitted by droplets, or by contacting lesions or body fluids, or by contacting clothes or bedding contaminated with pus or other damaging substances.
Professor Xu Jianqing, director of Shanghai Institute of emerging infectious diseases, told the first financial reporter: "in the past, there have been cases that monkeypox can be transmitted through contact between people, but the case of sexual transmission seems to be the first discovery. Of course, sexual transmission is also a special form of contact transmission."
What is the correlation between "stephanine" and "monkeypox" concept stocks?
Monkeypox virus spread to 15 countries! Concept stocks are now 20cm trading institutions such interpretation
Monkeypox virus spread to 15 countries! Concept stocks rose sharply, and some companies have received orders for small batch testing kits
